A kind of hybrid membrane with self-luminescent property was prepared by mixing rare earth nanoparticles of nano-Sr4Al2O4: Eu2+, Dy3+ into the casting solution dissolved with polyvinylidene fluoride (PVDF), and then coprecipitated through non-solvent induced phase separation (NIPS) method. Membrane were characterized by luminescent intensity, scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle measurement, and the results showed that the membranes with the nano-Sr4Al2O4: Eu2+, Dy3+ content of 0.75 wt% have the highest luminescent intensity and the lowest contact angle, but further increasing the nanoparticle content will decrease the surface pore density and change the cross-sectional structure. Meanwhile, the membrane permeability and the rejection rate proved that the addition of nano-Sr4Al2O4: Eu2+, Dy3+ effectively improved the flux of water and Bovine Serum Albumin/Humic Acid (BSA/HA) aqueous solution through the membrane. This hybrid membrane possessed the performance of real-time response to membrane pollution/cleaning, and finally an effectively improvement of anti-pollution property. © 2020 Elsevier B.V.