In vivo inducing collagen regeneration of biodegradable polymer microspheres

doi:10.1093/rb/rbab042

CQUET-IR > 智慧健康学院

	In vivo inducing collagen regeneration of biodegradable polymer microspheres
	Zhang, Yixin1 ; Liang, Hanwen 2; Luo, Qian 2; Chen, Jianlin 2; Zhao, Nan 3; Gao, Wenxia 4; Pu, Yuji 5; He, Bin 5; Xie, Jing 6
	2021
发表期刊	Regenerative Biomaterials
ISSN	2056-3418
EISSN	2056-3426
卷号	8 期号:5
摘要	Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Herein, eight biodegradable polymers with different molecular weights, chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications. Polymer microspheres with 20-100 lm were prepared. The in vitro degradation study showed that poly (L-lactic-co-glycolic acid) 75/25 microspheres degraded the fastest, whereas poly (L-lactic acid) (PLLA) microspheres with intrinsic viscosity of 6.89 ([g] ¼ 6.89) with the highest molecular weight showed the slowest degradation rate. After these microspheres were fabricated dermal fillers according to the formula of SculptraVR, they were injected subcutaneously into the back skin of rabbits. In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres. The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time. PLLA ([g] ¼ 3.80) microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect. These properties of size, morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. © The Author(s) 2021. Published by Oxford University Press.
关键词	Biodegradable polymers Biodegradation Degradation Fillers Lactic acid Microspheres Molecular weight Clinical trial Collagen regeneration Degradation rate Dermal fillers Foreign body reactions In-vivo Poly-l-lactic acids Polymer microspheres Polymer particles Pre-clinical
DOI	10.1093/rb/rbab042
收录类别	EI ; SCIE
语种	英语
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000692614600008
出版者	Oxford University Press
EI入藏号	20214411085326
EI分类号	461.8 Biotechnology ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804.1 Organic Compounds ; 815.1 Polymeric Materials ; 931.3 Atomic and Molecular Physics
原始文献类型	Journal article (JA)
出版地	OXFORD
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.cqcet.edu.cn/handle/39TD4454/3053
专题	智慧健康学院
作者单位	1.School of Smart Health, Chongqing College of Electronic Engineering, Chongqing; 401331, China; 2.School of Laboratory Medicine, Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin Food, Chengdu Medical College, Chengdu; 610500, China; 3.Puliyan (Nanjing) Medical Science and Technology Co. LTD, Nanjing; 211500, China; 4.College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou; 325027, China; 5.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu; 610064, China; 6.Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou; 325000, China
第一作者单位	智慧健康学院
推荐引用方式 GB/T 7714	Zhang, Yixin,Liang, Hanwen,Luo, Qian,et al. In vivo inducing collagen regeneration of biodegradable polymer microspheres[J]. Regenerative Biomaterials,2021,8(5).
APA	Zhang, Yixin.,Liang, Hanwen.,Luo, Qian.,Chen, Jianlin.,Zhao, Nan.,...&Xie, Jing.(2021).In vivo inducing collagen regeneration of biodegradable polymer microspheres.Regenerative Biomaterials,8(5).
MLA	Zhang, Yixin,et al."In vivo inducing collagen regeneration of biodegradable polymer microspheres".Regenerative Biomaterials 8.5(2021).

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