Under investigation is a completely generalized Hirota–Satsuma–Ito equation in (2 + 1)-dimensional. Multiple lump solutions are obtained based on three test functions, including 1-, 2- and 3-order lump solutions. Subsequently, the interaction between lump wave and solitary waves, and the interaction solution between lump wave and periodic wave are studied by using the bilinear form. Final, the stability and phase velocity are investigated. In order to analyze the dynamic behavior of these solutions, some 3D plots and contour plots are given by Mathematica.